TY - JOUR
T1 - Niacin modulates macrophage polarization in Parkinson's disease
AU - Wakade, Chandramohan
AU - Giri, Banabihari
AU - Malik, Aneeq
AU - Khodadadi, Hesam
AU - Morgan, John C.
AU - Chong, Raymond K.
AU - Baban, Babak
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.
AB - Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.
KW - GPR109A
KW - Macrophage polarization
KW - Niacin
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=85046629527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046629527&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2018.05.002
DO - 10.1016/j.jneuroim.2018.05.002
M3 - Article
C2 - 29759143
AN - SCOPUS:85046629527
SN - 0165-5728
VL - 320
SP - 76
EP - 79
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -