Pharmacology and Toxicology

Projects

Projects per year 1988 2003 2007 2008 2009 2012 2019

• 3 Active
• 40 Finished
• 87 Not started

Projects per year

Search results

• Finished

  Novel peptide-based strategy to inhibit deleterious TNF signaling in nephrotoxic nephritis

  Lucas, R., MADAIO, M. & MADAIO, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/1/15 → 6/30/18

  Project: Research project

  • AP301 peptide 100%
  • Nephritis 90%
  • Podocytes 58%
  • Glomerulonephritis 50%
  • Peptides 36%

• Novel mechanistic pathways of cardiovascular disease in obesity

  Fulton, D. J., Stepp, D. W. & Stepp, D. W.

  National Heart, Lung, and Blood Institute

  4/1/15 → 3/31/19

  Project: Research project

  • NADPH Oxidase 1 100%
  • Galectin 3 79%
  • Obesity 52%
  • Cardiovascular Diseases 32%
  • Glucose 28%

• Airway and Lung Vascular Remodeling in COPD

  Su, Y.

  National Institutes of Health

  10/1/14 → 9/30/18

  Project: Research project

  • Calpain 100%
  • Vascular Remodeling 71%
  • Chronic Obstructive Pulmonary Disease 59%
  • Smoke 44%
  • Tobacco 43%

• Single-molecule and ensemble imaging of GPCR-G protein complexes in live cells

  Javitch, J., Lambert, N. A., Javitch, J., Javitch, J. A. & LAMBERT, N. A.

  National Institute of General Medical Sciences

  7/1/14 → 4/30/18

  Project: Research project

  • GTP-Binding Proteins 100%
  • G-Protein-Coupled Receptors 54%
  • Single Molecule Imaging 49%
  • Membrane Proteins 15%
  • Ligands 12%

• Impaired hippocampal function as a risk factor for Post-Traumatic Stress Disorder

  Vazdarjanova, A. I.

  National Institutes of Health

  4/1/13 → 3/31/17

  Project: Research project

  • Post-Traumatic Stress Disorders 100%
  • Veterans 15%
  • Costs and Cost Analysis 12%
  • Phenotype 11%
  • Psychological Extinction 11%

• Novel Strategies for prevention of diabetic vascular dysfunction.

  Caldwell, R. W., Lucas, R., Mellor, A. L., Caldwell, R. B., Dong, Y., Caldwell, R. W., CALDWELL, R. B., Dong, Y., Lucas, R., MELLOR, A. L. & Caldwell, R. W.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/1/12 → 8/31/15

  Project: Research project

  • Blood Vessels 100%
  • Type 2 Diabetes Mellitus 95%
  • Indoleamine-Pyrrole 2,3,-Dioxygenase 86%
  • Arginase 83%
  • Oxidants 44%

• Resveratrol as an adjunct to resuscitation fluid following hemorrhage injury

  Raju, R. P., RAJU, R. P., RAJU, R. P. & RAJU, R. P.

  National Institute of General Medical Sciences

  8/1/12 → 7/31/17

  Project: Research project

  • Resveratrol 100%
  • Resuscitation 63%
  • Wounds and Injuries 57%
  • Hemorrhage 46%
  • Sirtuin 1 26%

• Calpain Activates Intracellular TGF-beta1 in Pulmonary Hypertension

  Su, Y., SU, Y. & SU, Y.

  National Heart, Lung, and Blood Institute

  8/1/12 → 6/30/15

  Project: Research project

  • Calpain 100%
  • Pulmonary Hypertension 57%
  • Vascular Remodeling 54%
  • Pulmonary Artery 42%
  • Lung 37%

• Renovation of the cage wash facility at the MCG animal facility in Gracewood, GA

  Terry, A. V.

  NIH Office of the Director

  5/15/12 → 5/14/13

  Project: Research project

  • biomedical research 100%
  • research support 83%
  • biostatistics 74%
  • cages 73%
  • bottles 64%

• Role of Hippo-YAP Pathway in Smooth Muscle Phenotypic Modulation

  Zhou, J., ZHOU, J., ZHOU, J., ZHOU, J. & ZHOU, J.

  National Heart, Lung, and Blood Institute

  1/1/12 → 12/31/16

  Project: Research project

  • Smooth Muscle 100%
  • Smooth Muscle Myocytes 21%
  • Transcription Factors 18%
  • Preliminary Data 17%
  • Vascular Smooth Muscle 15%

• Endothelial Barrier Protection and Repair in Acute Lung Injury

  Catravas, J., Fulton, D. J., Black, S. M., Verin, A. D., Verin, A. D., Catravas, J., FULTON, D., Catravas, J., FULTON, D., Catravas, J., Verin, A., BLACK, S. & Verin, A.

  National Heart, Lung, and Blood Institute

  7/10/11 → 12/31/16

  Project: Research project

  • Acute Lung Injury 100%
  • Endothelial Cells 27%
  • Streptococcus pneumoniae plY protein 20%
  • Art 14%
  • Animals 12%

• Hydrophobic mismatch and self-association of TM proteins and beta2 adrenoreceptor

  Lambert, N. A. & LAMBERT, N. A.

  National Institute of General Medical Sciences

  1/1/11 → 12/31/13

  Project: Research project

  • G-Protein-Coupled Receptors 100%
  • Proteins 43%
  • alpha-Helical Protein Conformation 23%
  • HEK293 Cells 21%
  • Cell Surface Receptors 21%

• Protective activity of the lectin-like domain of TNF in permeability edema

  Lucas, R., Lucas, R., Lucas, R. & Lucas, R.

  National Heart, Lung, and Blood Institute

  8/1/10 → 11/30/14

  Project: Research project

  • Streptococcus pneumoniae plY protein 100%
  • AP301 peptide 82%
  • Lectins 48%
  • Bacterial Pneumonia 40%
  • Epithelial Sodium Channels 31%

• Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse

  Terry, A. V., TERRY, A. V., TERRY, A. V., TERRY, A., TERRY, A., TERRY, A., TERRY, A. V. & TERRY, A. V.

  National Institute on Drug Abuse

  4/1/10 → 2/29/16

  Project: Research project

  • Short-Term Memory 100%
  • Choline 85%
  • Sensory Gating 61%
  • Cognition 41%
  • Pharmacology 41%

• Activators of Nrf2/ARE pathway as therapeutic target for Parkinson's Disease

  Thomas, B.

  National Institutes of Health

  6/1/09 → 9/30/11

  Project: Research project

  • Antioxidant Response Elements 100%
  • NF-E2-Related Factor 2 98%
  • Triterpenes 69%
  • Parkinson Disease 60%
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 34%

• Emotional learning-induced changes of neuronal representations in the hippocampal

  Vazdarjanova, A. I. & VAZDARJANOVA, A.

  National Institute of Mental Health

  5/15/09 → 4/30/12

  Project: Research project

  • Basolateral Nuclear Complex 100%
  • Learning 66%
  • Electronic Data Processing 65%
  • Entorhinal Cortex 63%
  • Memory Consolidation 49%

• Metabolic Determinants of Cardiovascular Dysfunction in Obesity

  Fulton, D. J., Stepp, D. W., FULTON, D. J., Stepp, D. W., FULTON, D. J. & Stepp, D. W.

  National Heart, Lung, and Blood Institute

  1/1/09 → 11/30/14

  Project: Research project

  • Obese Mice 100%
  • Non-Receptor Type 1 Protein Tyrosine Phosphatase 99%
  • Insulin Resistance 93%
  • Obesity 91%
  • Receptor for Advanced Glycation End Products 85%

• Procognitive and Antipsychotic Actions of JWS-USC-75-IX

  Terry, A. V., TERRY, A. V. & TERRY, A.

  National Institute on Aging

  8/1/08 → 11/30/10

  Project: Research project

  • Antipsychotic Agents 100%
  • Behavioral Symptoms 95%
  • Alzheimer Disease 84%
  • Ranitidine 39%
  • Animal Models 33%

• The biological clock, the endothelium, and vascular remodeling

  Rudic, R. D.

  National Institutes of Health

  8/1/08 → 6/30/14

  Project: Research project

  • Biological Clocks 100%
  • Vascular Remodeling 80%
  • Endothelium 57%
  • Blood Vessels 39%
  • Circadian Clocks 36%

• Role of MyD88-5 in the pathogenesis of Parkinson's disease

  Thomas, B.

  National Institutes of Health

  7/16/08 → 6/30/15

  Project: Research project

  • Parkinson Disease 100%
  • Synucleins 63%
  • Mitogen-Activated Protein Kinase 10 59%
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 42%
  • Knockout Mice 23%

• eNOS-actin Interaction and Oxygen in Lung Endothelium

  Su, Y., SU, Y., SU, Y., SU, Y., SU, Y. & SU, Y.

  National Heart, Lung, and Blood Institute

  7/1/08 → 6/30/15

  Project: Research project

  • Nitric Oxide Synthase Type III 100%
  • Actins 48%
  • Oxygen 16%
  • Endothelium 15%
  • Hyperoxia 14%

• INFLUENCE OF AGING ON MITOCHONDRIAL GENE EXPRESSION FOLLOWING TRAUMA-HEMORRHAGE

  Raju, R. P. & RAJU, R. P.

  National Institute on Aging

  4/1/08 → 3/31/11

  Project: Research project

  • mitochondrial genes 100%
  • gene expression 35%
  • DNA microarrays 31%
  • hemorrhage 29%
  • animal models 20%

• GPCR signaling complexes in living cells

  Lambert, N. A., LAMBERT, N. A. & LAMBERT, N. A.

  National Institute of General Medical Sciences

  9/25/07 → 12/31/17

  Project: Research project

  • G-Protein-Coupled Receptors 100%
  • GTP-Binding Proteins 79%
  • Membrane Proteins 16%
  • Pharmaceutical Preparations 16%
  • RGS Proteins 15%

• Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders

  Buccafusco, J., Terry, A. V., TERRY, A. V., Buccafusco, J. J. & Buccafusco, J.

  National Institute on Aging

  9/1/07 → 6/30/13

  Project: Research project

  • Cotinine 100%
  • Nicotine 23%
  • Aptitude 12%
  • Short-Term Memory 11%
  • Haplorhini 10%

• Tyrosine phosphorylation of endothelial nitric oxide synthase

  Fulton, D. J., FULTON, D., FULTON, D., FULTON, D. & FULTON, D. J.

  National Heart, Lung, and Blood Institute

  4/1/07 → 3/31/13

  Project: Research project

  • Nitric Oxide Synthase Type III 100%
  • Phosphorylation 48%
  • Nitric Oxide 19%
  • Tyrosine 16%
  • Blood Vessels 10%

• ER-to-Golgi traffic and signal regulation of GPCRs

  Wu, G., WU, G., WU, G., WU, G., WU, G., WU, G., WU, G., WU, G. & WU, G.

  National Institute of General Medical Sciences

  5/1/06 → 4/30/16

  Project: Research project

  • G-Protein-Coupled Receptors 100%
  • Endoplasmic Reticulum 71%
  • Adrenergic Agents 40%
  • CCR10 Receptors 14%
  • Nephrogenic Diabetes Insipidus 12%

• An epsilon PKC interacting protein in preconditioning

  Johnson, J. A. & JOHNSON, J. A.

  National Heart, Lung, and Blood Institute

  6/1/05 → 4/30/10

  Project: Research project

  • Protein Kinase C-epsilon 100%
  • Electron Transport Complex IV 28%
  • Cardiac Myocytes 22%
  • Proteins 21%
  • Isoenzymes 14%

• Peripheral clocks in metabolism and diabetes

  Rudic, R. D.

  National Institutes of Health

  4/1/05 → 3/31/10

  Project: Research project

  • Lipids 100%
  • Circadian Rhythm 96%
  • Adipokines 69%
  • Homeostasis 67%
  • Resistin 40%

• Calcium Signaling &Prefrontal Deficits in Schizophrenia

  Arnsten, A. F. T., Krystal, J., Selemon, L., Gao, W., Levenson, R., Rakic, P., Lidow, M., Bradberry, C., Mathalon, D., Mc Cormick, D., Friedman, H., McCormick, D., Bergson, C. M., Bradberry, C., Lidow, M., Selemon, L., Mathalon, D., Friedman, H., Levenson, R., Rakic, P., GAO, W. & ARNSTEN, A.

  12/12/03 → 11/30/09

  Project: Research project

  • Receptor-Interacting Protein Serine-Threonine Kinases 100%
  • Dopamine 90%
  • Schizophrenia 72%
  • Calcium Signaling 42%
  • Cognitive Dysfunction 29%

• MENTORING IN CARDIOVASCULAR BIOLOGY

  Worthylake, R., Wainford, R. D., Lanier, S. M., Kapusta, D., Park, F., Catling, A., Strong, J., Boulares, H., Zhang, C., Dick, G., Varner, K. J., Rocic, P., Lazartigues, E., Bazan, H., Woods, T. C., Filipeanu, C., Breslin, J., Kelly, B., Wu, G., Park, F., Catling, A., Boulares, H., Strong, J. & LANIER, S.

  9/1/03 → 6/30/13

  Project: Research project

  • mentoring 100%
  • blood vessels 34%
  • Biological Sciences 31%
  • pharmacology 25%
  • research programs 24%

• Regulation of eNOS by Subcellular Targeting

  Fulton, D. J. & FULTON, D. J.

  National Heart, Lung, and Blood Institute

  7/1/03 → 6/30/08

  Project: Research project

  • Nitric Oxide Synthase Type III 100%
  • Cell Membrane 23%
  • Calcium 19%
  • Cardiovascular Diseases 10%
  • Phosphorylation 9%

• Antipsychotics: Temporal Effects on Cognitive Function

  Terry, A. V., TERRY, A. V. & TERRY, A. V.

  National Institutes of Health, National Institute of Mental Health

  3/1/03 → 2/28/08

  Project: Research project

  • Antipsychotic Agents 100%
  • Cognition 68%
  • Cholinergic Agents 41%
  • Cholinergic Neurons 32%
  • Cognitive Dysfunction 29%

• Cholinesterase Inhibitors, Axonal transport, and Memory

  Terry, A. V., TERRY, A. V., TERRY, A. V., TERRY, A., TERRY, A., TERRY, A., TERRY, A., TERRY, A., TERRY, A. & TERRY, A. V.

  National Institute of Environmental Health Sciences

  1/1/03 → 10/31/15

  Project: Research project

  • Organophosphates 100%
  • Axonal Transport 98%
  • Cholinergic Agents 36%
  • Kinesin 33%
  • Memory 28%

• PKC Signaling in cAMP-Induced Pulmonary Vasodilation

  Barman, S. A., Barman, S. A. & BARMAN, S.

  National Heart, Lung, and Blood Institute

  7/1/01 → 12/31/11

  Project: Research project

  • Lung 100%
  • Protein Kinase C 88%
  • Familial Primary Pulmonary Hypertension 73%
  • Pulmonary Artery 51%
  • Vasodilator Agents 37%

• The Role of Calcyon in Synaptic Integration

  Bergson, C. M.

  4/1/01 → 3/31/06

  Project: Research project

  • calcyon 100%
  • Dopamine D1 Receptors 23%
  • Inositol 1,4,5-Trisphosphate Receptors 16%
  • Dendritic Spines 14%
  • fura-2-am 9%

• CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVAL

  Vogel, S. S., Lambert, N. A. & VOGEL, S.

  National Institute of Neurological Disorders and Stroke

  5/24/00 → 2/28/05

  Project: Research project

  • Exocytosis 100%
  • P-Type Calcium Channels 74%
  • Membranes 62%
  • Eggs 48%
  • Calcium 40%

• CELLULAR MECHANISMS OF RETINAL ANGIOGENESIS

  Caldwell, R. W., Caldwell, R. B., Caldwell, R. B., Caldwell, R. B., Caldwell, R. W., CALDWELL, R., CALDWELL, R. B., Caldwell, R. W., Caldwell, R. W., CALDWELL, R. B., Caldwell, R. W., CALDWELL, R. B., Caldwell, R. W., CALDWELL, R., Caldwell, R. W. & CALDWELL, R.

  National Eye Institute

  3/1/98 → 2/28/18

  Project: Research project

  • Vascular Endothelial Growth Factor A 100%
  • Nitric Oxide 47%
  • Retinal Vessels 19%
  • Endothelial Cells 18%
  • Growth and Development 17%

• MECHANISM OF FUNCTIONAL PRESYNAPTIC HETEROGENEITY IN CNS

  Lambert, N. A. & LAMBERT, N. A.

  National Institute of Neurological Disorders and Stroke

  4/1/97 → 1/31/08

  Project: Research project

  • synapse 100%
  • calcium 27%
  • information storage 20%
  • information processing 16%
  • action potentials 15%

• DETERMINANTS OF DOPAMINE RECEPTOR FUNCTION

  Bergson, C. M.

  1/1/97 → 12/31/01

  Project: Research project

  • Dopamine Receptors 100%
  • Signal Transduction 69%
  • Proteins 54%
  • Mental Disorders 47%
  • Two-Hybrid System Techniques 37%

• CHARACTERIZATION OF VASCULAR TONE ON LUNG FLUID BALANCE

  Barman, S. A. & Barman, S. A.

  National Institutes of Health, National Heart, Lung, and Blood Institute

  5/10/91 → 4/30/97

  Project: Research project

  • Blood Vessels 100%
  • Lung 70%
  • Lung Injury 59%
  • Vascular System Injuries 42%
  • Cholinergic Receptors 41%